By Jacob Bean
Works pointed out in Abbreviated Form
Notices and Illustrations
Index of Former Owners
Index of Artists
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Extra resources for 17th century Italian drawings in the Metropolitan Museum of Art
In rodent models, neonatal exposure to exogenous estrogen results in a dose dependent alteration of adult prostate size and histology. However, targeted disruption of the estrogen receptors (ER) a and P in mice do not conclusively show a role for either ER in prostate development, potentially indicating that exogenous estrogens may be acting at least in part through AR to influence prostate growth. Estrogens and androgens are structurally similar with the major difference occurring at the C-3 position of the steroidal A-ring where 30 Dihydrotestosterone dihydroxytestosterone (DHT) carries a keto group and E2 carries a phenolic hydroxyl.
By comparing the effects of various ER-ligands on regulating prostate cancer cell growth and proliferation in cell culture and in animal models, the ligand specificity of estrogen action will be determined. The anti-androgenic and antitumor effects of 17alpha-estradiol will be further explored in cell culture and in a xenograft animal model of prostate cancer. Elucidation of receptor-isoform and ligand specificity of estrogen-androgen interaction will facilitate our understanding of sex-steroid interaction in prostate physiology and pathogenesis, and the development of specific ER-ligands for the treatment of androgendependent and androgen-independent prostate cancer.
Future directions in POR include: (1) Family- based behavioral lifestyle treatment of pediatric obesity; (2) multi center investigation of the emerging epidemic of obesity-related Type 2 diabetes in children, especially African-American and Latino; (3) development of noninvasive methods, p31 NMR spectroscopy to study muscle energy metabolism in children; (4) intervention/prevention strategies for childhood obesity. Generate_Screen • Project Title: ANDROGENS MALE PSEUDOHERMAPHRODITISM--THE BIOLOGY OF Principal Investigator & Institution: Imperato, Julianne; Weill Medical College of Cornell Univ New York, Ny 10021 Timing: Fiscal Year 2003 Summary: This abstract is not available.
17th century Italian drawings in the Metropolitan Museum of Art by Jacob Bean